Dissolving Film Could Replace Eye Drops for Ocular Drug Delivery
A dissolving film now under development could one day replace eye drops for the treatment of eye conditions.
In a new study published in ACS Nano, a journal of the American Chemical Society, the “nanowafer” was found twice as effective in treating corneal neovascularization in mice. This delivery vehicle has an advantage over conventional drop based deliver of drugs in that it only need be applied daily or every other day rather than with multiple dose regimens required with drops. Further the nanowafer system has been demonstrated to deliver more drug to the tissues a feature that will go a long way in promoting patient compliance in the treatment of eye conditions.
The film is composed of four water soluble polymers that are baked over a template that indents the surface with tiny pockets that contain and release drugs over time. In the mouse eye trials the wafer was loaded with axitnib in the treatment of corneal burn induced neovascularization. At the end of the study period researchers determined less neovascularization and improved healing in the nanowafer group as compared to those lab animals treated topically with 0.1% axitnib drops.
The use of this delivery system in the treatment of human eye disease is just around the corner.